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KMID : 0603820120180040345
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 4 p.345 ~ p.354
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The Anti-inflammatory Mechanism of Xanthoangelol E is Through the Suppression of NF-κB/Caspase-1 Activation in LPS-stimulated Mouse Peritoneal Macrophage
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Seoa Jung-Ho
Kim Su-Jin
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Abstract
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Angelica keiskei has exhibited numerous pharmacological effects including antitumor, antimetastatic, and antidiabetic effects. However, the anti-inflammatory effects and mechanisms employed by xanthoangelol E isolated from Angelica keiskei are incompletely understood. In this study, we attempted to determine the effects of Xanthoangelol E on the lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophage. The findings of this study demonstrated that xanthoangelol E inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and prostaglandin E2 (PGE2). Xanthoangelol E inhibited the enhanced levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) caused by LPS. Additionally, we showed that the anti-inflammatory effect of xanthoangelol E is through the regulation of the activation of nuclear factor (NF)-κB and caspase-1. These results provide novel insights into the pharmacological actions of xanthoangelol E as a potential candidate for the development of new drugs to treat inflammatory diseases.
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KEYWORD
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Xanthoangelol, Inflammation, Macrophage, Nuclear factor-kappa B, Caspase-1
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